Drug Information

Drug General Information
Drug ID
D0O1ZI
Former ID
DCL001156
Drug Name
AZD8329
Drug Type
Small molecular drug
Indication Diabetes; Obesity [ICD9: 250, 278; ICD10:E08-E13, E66] Phase 1 [542690], [550290]
Company
AstraZeneca
Structure
Download
2D MOL
Formula
C25H31N3O3
InChI
InChI=1S/C25H31N3O3/c1-25(2,3)22-20(13-26-28(22)19-6-4-16(5-7-19)24(30)31)23(29)27-21-17-9-14-8-15(11-17)12-18(21)10-14/h4-7,13-15,17-18,21H,8-12H2,1-3H3,(H,27,29)(H,30,31)
InChIKey
XWBXJBSVYVJAMZ-UHFFFAOYSA-N
PubChem Compound ID
25006684
PubChem Substance ID
57528056, 99229830, 137175217, 141162443, 163324698, 163348359, 177013111, 198975595, 223366048, 224305608, 226918734, 245139291
Target and Pathway
Target(s) Corticosteroid 11-beta-dehydrogenase, isozyme 1 Target Info Inhibitor [550290]
KEGG Pathway Steroid hormone biosynthesis
Metabolism of xenobiotics by cytochrome P450
Metabolic pathways
Chemical carcinogenesis
NetPath Pathway IL1 Signaling Pathway
FSH Signaling Pathway
PathWhiz Pathway Steroidogenesis
Reactome Glucocorticoid biosynthesis
WikiPathways Prostaglandin Synthesis and Regulation
Metabolism of steroid hormones and vitamin D
Glucocorticoid & Mineralcorticoid Metabolism
References
Ref 542690(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7715).
Ref 550290Clinical pipeline report, company report or official report of AstraZeneca (2011).
Ref 550290Clinical pipeline report, company report or official report of AstraZeneca (2011).

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