Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0O2AC
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| Former ID |
DIB012984
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| Drug Name |
FR-145237
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| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Terminated | [1] | ||
| Company |
Fujisawa Pharmaceutical Co Ltd
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| Structure |
|
Download2D MOL |
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| Canonical SMILES |
c1(c(c2c(o1)ccc(c2)C)c1ccc(cc1)Cl)CN(C(=O)Nc1c(cc(cc1F)<br />F)F)Cc1ccccc1
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| CAS Number |
CAS 146011-65-6
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| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Modulator | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006465) | ||||
| REF 2 | Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall. Biochim Biophys Acta. 1995 Dec 7;1259(3):254-60. | ||||
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