Drug General Information
Drug ID	D0O2AC
Former ID	DIB012984
Drug Name	FR-145237
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[546129]
Company	Fujisawa Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(c2c(o1)ccc(c2)C)c1ccc(cc1)Cl)CN(C(=O)Nc1c(cc(cc1F)<br />F)F)Cc1ccccc1
CAS Number	CAS 146011-65-6
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Modulator	[534076]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 546129	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006465)
Ref 534076	Effect of FR145237, a novel ACAT inhibitor, on atherogenesis in cholesterol-fed and WHHL rabbits. Evidence for a direct effect on the arterial wall. Biochim Biophys Acta. 1995 Dec 7;1259(3):254-60.

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