Drug Information

Drug General Information
Drug ID
D0O4TF
Former ID
DIB010124
Drug Name
MB-11262
Synonyms
MB-11262; Glucagon antagonists (oral, type 2 diabetes); Glucagon antagonists (oral, type 2 diabetes), Ligand Pharmaceuticals; Glucagon antagonists (oral, type 2 diabetes), Ligand/Metabasis
Indication Non-insulin dependent diabetes [ICD10:E11.9] Investigative [543641]
Company
Metabasis Therapeutics Inc
Structure
Download
2D MOL
Target and Pathway
Target(s) Glucagon receptor Target Info Antagonist [543641]
KEGG Pathway Neuroactive ligand-receptor interaction
Glucagon signaling pathway
Reactome Glucagon signaling in metabolic regulation
G alpha (q) signalling events
G alpha (s) signalling events
Glucagon-type ligand receptors
WikiPathways GPCRs, Class B Secretin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 543641(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 251).
Ref 543641(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 251).

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