Drug Information

Drug General Information
Drug ID
D0O5TQ
Former ID
DAP000260
Drug Name
Pentagastrin
Synonyms
Peptavlon; Peptavlon (TN); Pentagastrin (JAN/USAN/INN); (3S)-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-3-(1H-indol-3-yl)-2-[3-(2-methylpropoxycarbonylamino)propanoylamino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-oxobutanoic acid
Drug Type
Small molecular drug
Indication Diagnostic imaging [ICD9: 331; ICD10:G30, I73.9] Approved [538484], [543256]
Therapeutic Class
Diagnostic Agents
Structure
Download
2D MOL

3D MOL
Formula
C37H49N7O9S
InChI
InChI=1S/C37H49N7O9S/c1-22(2)21-53-37(52)39-15-13-31(45)41-29(18-24-20-40-26-12-8-7-11-25(24)26)35(50)42-27(14-16-54-3)34(49)44-30(19-32(46)47)36(51)43-28(33(38)48)17-23-9-5-4-6-10-23/h4-12,20,22,27-30,40H,13-19,21H2,1-3H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)/t27-,28-,29-,30-/m0/s1
InChIKey
ALXRNCVIQSDJAO-KRCBVYEFSA-N
CAS Number
CAS 5534-95-2
PubChem Compound ID
444007
PubChem Substance ID
36887127, 46507747, 53788671, 57404587, 79253197, 104631117, 134337574, 135652381, 136071537, 137125963, 137241217, 160963531, 180372014, 229288604
SuperDrug ATC ID
V04CG04
SuperDrug CAS ID
cas=005534952
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info Agonist [535744], [536753], [537852], [537987]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538484FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 017048.
Ref 543256(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 870).
Ref 535744Molecular cloning of the human brain and gastric cholecystokinin receptor: structure, functional expression and chromosomal localization. Biochem Biophys Res Commun. 1992 Nov 30;189(1):296-303.
Ref 536753Functional interactions between endocannabinoid and CCK neurotransmitter systems may be critical for extinction learning. Neuropsychopharmacology. 2009 Jan;34(2):509-21. Epub 2008 Jun 25.
Ref 537852The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization. J Biol Chem. 1993 Apr 15;268(11):8164-9.
Ref 537987The effects of central administration of the CCK-B receptor agonist pentagastrin on feeding and cortisol release in sheep. Methods Find Exp Clin Pharmacol. 1996 May;18(4):235-8.

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