Drug Information

Drug General Information
Drug ID
D0O5UF
Former ID
DIB010007
Drug Name
CNX-011
Synonyms
CNX-011; GPR 40 agonists (type 2 diabetes); CNX-011-67; GPR 40 agonists (type 2 diabetes), Connexios LifeSciences; G-protein coupled receptor 40 agonists (type 2 diabetes), Connexios Life Sciences
Indication Non-insulin dependent diabetes [ICD10:E11.9] Investigative [543582]
Company
Connexios Life Sciences Pvt Ltd
Target and Pathway
Target(s) GPR40 Target Info Agonist [543582]
KEGG Pathway Insulin secretion
Reactome G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways GPCRs, Class A Rhodopsin-like
Incretin Synthesis, Secretion, and Inactivation
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 543582(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 225).
Ref 543582(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 225).

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