Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0O5WP
|
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| Former ID |
DAP000590
|
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| Drug Name |
Docetaxel
|
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| Synonyms |
EmDOC; TXL; Taxotere; Docetaxel anhydrous; ANX-514; Docetaxel (INN); Docetaxel, Trihydrate; RP-56976; SDP-014; Taxotere (TN); Taxotere(R); XRP-6976L; Docetaxel 114977-28-5; N-debenzoyl-N-Boc-10-deacetyl taxol; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel; N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol; (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate; 4-(acetyloxy)-13alpha-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7beta,10beta-trihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate
|
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| Drug Type |
Small molecular drug
|
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| Therapeutic Class |
Anticancer Agents
|
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| Company |
Sanofi-Aventis
|
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| Structure |
|
Download2D MOL |
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| Formula |
C43H53NO14
|
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| InChI |
InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
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| InChIKey |
ZDZOTLJHXYCWBA-VCVYQWHSSA-N
|
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| CAS Number |
CAS 114977-28-5
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
13410, 494081, 822539, 833094, 7890914, 7979114, 10249812, 12014196, 14791415, 14815974, 17424977, 24845209, 26683886, 46225079, 46506766, 53790583, 56310805, 56310954, 56311107, 56311313, 56311574, 56312625, 56312880, 56312940, 56312941, 56313207, 56313989, 56314033, 56314070, 56314178, 56314280, 57346703, 78743198, 81044598, 87678200, 92308884, 92711403, 96024562, 99319097, 103172104, 104418276, 117664410, 117682515, 124950708, 126606827, 126630894, 126657365, 134337881, 136340291, 136375539
|
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| SuperDrug ATC ID |
L01CD02
|
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| SuperDrug CAS ID |
cas=114977285
|
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| Target and Pathway | |||||
| Target(s) | Tubulin | Target Info | Inhibitor | [536155] | |
| References | |||||
| Ref 536155 | Docetaxel: a review of its use in metastatic breast cancer. Drugs. 2005;65(17):2513-31. | ||||
| Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| Ref 541891 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6809). | ||||
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