Drug Information

Drug General Information
Drug ID
D0O6WV
Former ID
DNC009048
Drug Name
BMS-777607
Drug Type
Small molecular drug
Indication Discovery agent Phase 1/2 [522210], [542869]
Structure
Download
2D MOL

3D MOL
Formula
C25H19ClF2N4O4
InChI
InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
InChIKey
VNBRGSXVFBYQNN-UHFFFAOYSA-N
PubChem Compound ID
24794418
PubChem Substance ID
49738159, 57114099, 57410837, 57560543, 103591700, 104253214, 123051085, 124757339, 125164143, 126661005, 134346253, 135338476, 136023428, 136340176, 136367518, 136920301, 137276001, 141316591, 141588713, 144115735, 152258392, 160647229, 162011759, 162037667, 162202675, 163643077, 163907984, 165246668, 170482363, 172913021, 174525823, 174526525, 177749431, 180386849, 185978325, 198952609, 223435807, 223656188, 223705035, 224179623, 228686285, 242060318, 245690993, 249565636, 251971382, 252110162, 252215018, 252451749
Target and Pathway
Target(s) Hepatocyte growth factor receptor Target Info Inhibitor [529996]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Axon guidance
Focal adhesion
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Central carbon metabolism in cancer
Pathway Interaction Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Arf6 signaling events
Signaling events mediated by TCPTP
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
Syndecan-1-mediated signaling events
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Regulation of retinoblastoma protein
Reactome Sema4D mediated inhibition of cell attachment and migration
WikiPathways TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Signaling Pathways in Glioblastoma
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Semaphorin interactions
References
Ref 522210ClinicalTrials.gov (NCT00605618) Multiple Ascending Dose Study of BMS-777607 in Subjects With Advanced or Metastatic Solid Tumors. U.S. National Institutes of Health.
Ref 542869(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7953).
Ref 529996J Med Chem. 2009 Mar 12;52(5):1251-4.Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

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