Drug Information

Drug General Information
Drug ID
D0O8AK
Former ID
DIB018824
Drug Name
alpha-methylserine-O-phosphate
Synonyms
alpha-MSOP
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538874]
Structure
Download
2D MOL
Formula
C4H10NO6P
InChI
InChI=1S/C4H10NO6P/c1-4(5,3(6)7)2-11-12(8,9)10/h2,5H2,1H3,(H,6,7)(H2,8,9,10)
InChIKey
GSFCOAGADOGIGE-UHFFFAOYSA-N
PubChem Compound ID
3964633
PubChem Substance ID
5819530, 7980679, 9422471, 15340469, 26751900, 35159838, 50025456, 53333181, 57356659, 85209530, 91746367, 112508476, 126382447, 132557643, 135650668, 163136094, 238184057, 241181904, 242242477
Target and Pathway
Target(s) Metabotropic glutamate receptor 8 Target Info Antagonist [526630]
Metabotropic glutamate receptor 2 Target Info Antagonist [534581]
Metabotropic glutamate receptor 7 Target Info Antagonist [525945]
mGlu6 receptor Target Info Antagonist [526630]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04080:Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addictionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
References
Ref 538874(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1398).
Ref 525945Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54.
Ref 526630The metabotropic glutamate receptors: structure, activation mechanism and pharmacology. Curr Drug Targets CNS Neurol Disord. 2002 Jun;1(3):297-317.
Ref 534581Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes. Br J Pharmacol. 1998 Feb;123(3):497-504.

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