Drug Information

Drug General Information
Drug ID
D0O9HS
Former ID
DNC012591
Drug Name
1-(2-Chloro-phenyl)-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528039]
Structure
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2D MOL

3D MOL
Formula
C10H13ClN2
Canonical SMILES
C1CN(CCN1)C2=CC=CC=C2Cl
InChI
1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
InChIKey
PWZDJIUQHUGFRJ-UHFFFAOYSA-N
PubChem Compound ID
415628
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Inhibitor [528039]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [528039]
Alpha-1D adrenergic receptor Target Info Inhibitor [528039]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04024:cAMP signaling pathway
Serotonergic synapsehsa04020:Calcium signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
GPCR downstream signalingWP58:Monoamine GPCRs
GPCRs, Other
References
Ref 528039J Med Chem. 1991 Jun;34(6):1850-4.Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.
Ref 528039J Med Chem. 1991 Jun;34(6):1850-4.Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands.

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