Drug General Information
Drug ID	D0O9NE
Former ID	DNC004383
Drug Name	TRISMETHOXYRESVERATROL
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[526231]
Structure		Download 2D MOL 3D MOL
Formula	C17H18O3
Canonical SMILES	COC1=CC=C(C=C1)C=CC2=CC(=CC(=C2)OC)OC
InChI	1S/C17H18O3/c1-18-15-8-6-13(7-9-15)4-5-14-10-16(19-2)12-17(11-14)20-3/h4-12H,1-3H3/b5-4+
InChIKey	GDHNBPHYVRHYCC-SNAWJCMRSA-N
PubChem Compound ID	5388063
Target and Pathway
Target(s)	Multidrug resistance protein 1	Target Info	Inhibitor	[528198]
	Cytochrome P450 1B1	Target Info	Inhibitor	[526231]
	Proto-oncogene c-Abl	Target Info	Inhibitor	[528198]
BioCyc Pathway	Superpathway of tryptophan utilization
	Superpathway of melatonin degradation
	Melatonin degradation I
KEGG Pathway	ABC transporters
	Bile secretion
	MicroRNAs in cancerhsa00140:Steroid hormone biosynthesis
	Tryptophan metabolism
	Metabolism of xenobiotics by cytochrome P450
	Ovarian steroidogenesis
	Chemical carcinogenesis
	MicroRNAs in cancerhsa04012:ErbB signaling pathway
	Ras signaling pathway
	Cell cycle
	Axon guidance
	Neurotrophin signaling pathway
	Pathogenic Escherichia coli infection
	Shigellosis
	Pathways in cancer
	MicroRNAs in cancer
	Chronic myeloid leukemia
	Viral myocarditis
NetPath Pathway	IL2 Signaling Pathway
	TCR Signaling PathwayNetPath_23:TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Axon guidance mediated by Slit/Robo
Pathway Interaction Database	HIF-1-alpha transcription factor networkp73pathway:p73 transcription factor network
	ATM pathway
	Regulation of Telomerase
	Posttranslational regulation of adherens junction stability and dissassembly
	Lissencephaly gene (LIS1) in neuronal migration and development
	PDGFR-beta signaling pathway
	Neurotrophic factor-mediated Trk receptor signaling
	Validated transcriptional targets of TAp63 isoforms
	p53 pathway
	Regulation of retinoblastoma protein
Reactome	ABC-family proteins mediated transportR-HSA-211976:Endogenous sterolsR-HSA-2029482:Regulation of actin dynamics for phagocytic cup formation
	CDO in myogenesis
	RHO GTPases Activate WASPs and WAVEs
	HDR through Single Strand Annealing (SSA)
	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Nuclear Receptors in Lipid Metabolism and Toxicity
	Abacavir transport and metabolism
	Multi Drug Resistance Protein 1 (Glycoprotein 1) Regulation
	Integrated Pancreatic Cancer Pathway
	Allograft Rejection
	Drug Induction of Bile Acid Pathway
	Codeine and Morphine MetabolismWP702:Metapathway biotransformation
	Estrogen metabolism
	Benzo(a)pyrene metabolism
	Tamoxifen metabolism
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	Sulindac Metabolic Pathway
	Arylhydrocarbon receptor (AhR) signaling pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	miR-targeted genes in adipocytes - TarBase
	Phase 1 - Functionalization of compoundsWP2864:Apoptosis-related network due to altered Notch3 in ovarian cancer
	Fcgamma receptor (FCGR) dependent phagocytosis
	ATM Signaling Pathway
	Retinoblastoma (RB) in Cancer
	Pathogenic Escherichia coli infection
	Regulation of Microtubule Cytoskeleton
	Integrated Breast Cancer Pathway
	Signaling by Robo receptor
	Myogenesis
	Factors involved in megakaryocyte development and platelet production
References
Ref 526231	J Med Chem. 2002 Jan 3;45(1):160-4.Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors.
Ref 526231	J Med Chem. 2002 Jan 3;45(1):160-4.Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors.
Ref 528198	J Med Chem. 2006 May 18;49(10):3012-8.Identification of a terphenyl derivative that blocks the cell cycle in the G0-G1 phase and induces differentiation in leukemia cells.

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