Drug Information

Drug General Information
Drug ID
D0OH2P
Former ID
DIB018097
Drug Name
(S)-(+)-CBPG
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540366]
Structure
Download
2D MOL
Formula
C8H11NO4
InChI
InChI=1S/C8H11NO4/c9-4(5(10)11)7-1-8(2-7,3-7)6(12)13/h4H,1-3,9H2,(H,10,11)(H,12,13)/t4-,7?,8?/m1/s1
InChIKey
KNSHLWJBSDBBRH-XOJFDHPMSA-N
PubChem Compound ID
5311040
PubChem Substance ID
7978869, 11056226, 15120700, 15586690, 39340769, 52693785, 57359334, 103216813, 103949151, 114155115, 117518367, 128408754, 131400561, 163058346, 178100427, 180666391, 227531750, 252356524
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Agonist [525552]
Metabotropicglutamate receptor 1 Target Info Antagonist [525552]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's diseasehsa04020:Calcium signaling pathway
FoxO signaling pathway
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signalingP00027:Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-416476:G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCR downstream signaling
GPCRs, Other
References
Ref 540366(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3421).
Ref 525552Biochemical and electrophysiological studies on (S)-(+)-2-(3'-carboxybicyclo(1.1.1)pentyl)-glycine (CBPG), a novel mGlu5 receptor agonist endowed with mGlu1 receptor antagonist activity. Neuropharmacology. 1999 Jul;38(7):917-26.

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