Drug Information

Drug General Information
Drug ID
D0OJ5M
Former ID
DIB015946
Drug Name
OLPADRONIC ACID SODIUM SALT
Synonyms
Dimethyl-APD; IG-8801; Olpadronic acid sodium salt < Rec INNM >; 3-(Dimethylamino)-1-hydroxypropylidene-1,1-diphosphonic acid monosodium salt
Drug Type
Small molecular drug
Indication Bone resorption [ICD10:M80] Investigative [525426]
Structure
Download
2D MOL

3D MOL
Formula
C5H15NO7P2
Canonical SMILES
CN(C)CCC(O)(P(=O)(O)O)P(=O)(O)O
InChI
1S/C5H15NO7P2/c1-6(2)4-3-5(7,14(8,9)10)15(11,12)13/h7H,3-4H2,1-2H3,(H2,8,9,10)(H2,11,12,13)
InChIKey
UGEPSJNLORCRBO-UHFFFAOYSA-N
CAS Number
CAS 63132-39-8
PubChem Compound ID
198716
PubChem Substance ID
10262999, 15197114, 33518364, 50070424, 50071064, 57399153, 77964628, 103241125, 113468424, 129363789, 135028239, 137021006, 142428949, 164231791, 164763845, 179150810, 184546911, 198937401, 226506247
Target and Pathway
Target(s) Farnesyl pyrophosphate synthase Target Info Modulator [525426]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Trans, trans-farnesyl diphosphate biosynthesis
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
References
Ref 525426Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4.
Ref 525426Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo. Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.