Drug Information

Drug General Information
Drug ID
D0OJ7S
Former ID
DIB020981
Drug Name
SR142948A
Synonyms
SR-142948A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538959]
Structure
Download
2D MOL
Formula
C39H51N5O6
InChI
InChI=1S/C39H51N5O6/c1-23(2)29-21-26(37(46)43(5)15-9-14-42(3)4)12-13-31(29)44-32(35-33(49-6)10-8-11-34(35)50-7)22-30(41-44)36(45)40-39(38(47)48)27-17-24-16-25(19-27)20-28(39)18-24/h8,10-13,21-25,27-28H,9,14-20H2,1-7H3,(H,40,45)(H,47,48)
InChIKey
LWULHXVBLMWCHO-UHFFFAOYSA-N
PubChem Compound ID
5311451
PubChem Substance ID
7980656, 11056515, 14815074, 39341125, 47731315, 47805619, 50112868, 50569217, 57359486, 85222213, 85788189, 113635343, 114156133, 125762525, 128552765, 134222691, 135651074, 136351150, 137142845, 137275715, 144239952, 162023294, 162223894, 175453055, 194172319, 196376815, 225052837, 233165741, 241375876, 249617535, 252156433, 252159998
Target and Pathway
Target(s) Neurotensin receptor type 1 Target Info Antagonist [534320]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538959(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1580).
Ref 534320Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther. 1997 Feb;280(2):802-12.

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