Drug Information

Drug General Information
Drug ID
D0OM0M
Former ID
DCL000448
Drug Name
AVE1625
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Discontinued in Phase 2 [547945]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C23H20Cl2F2N2O2S
Canonical SMILES
CS(=O)(=O)N(C1CN(C1)C(C2=CC=C(C=C2)Cl)C3=CC=C(C=C3)Cl)C<br />4=CC(=CC(=C4)F)F
InChI
1S/C23H20Cl2F2N2O2S/c1-32(30,31)29(21-11-19(26)10-20(27)12-21)22-13-28(14-22)23(15-2-6-17(24)7-3-15)16-4-8-18(25)9-5-16/h2-12,22-23H,13-14H2,1H3
InChIKey
IQQBRKLVEALROM-UHFFFAOYSA-N
CAS Number
CAS 358970-97-5
PubChem Compound ID
10278470
PubChem Substance ID
15283483, 22655955, 35449675, 78887532, 125335446, 134339063, 135359538, 137248677, 140903227, 162221514, 163123175, 198989891, 204380076, 226978313, 247604725, 252467495
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Antagonist [549823]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547945Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020616)
Ref 549823Pharma & Vaccines. Product Development Pipeline. April 29 2009.

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