Drug General Information
Drug ID	D0OR2S
Former ID	DIB005644
Drug Name	Broxaterol
Synonyms	Summair; Z-1170
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 3	[544547]
Company	Zambon Co SpA
Structure		Download 2D MOL 3D MOL
Formula	C9H15BrN2O2
Canonical SMILES	c1(cc(no1)Br)C(CNC(C)(C)C)O
CAS Number	CAS 76596-57-1
PubChem Compound ID	71149
Target and Pathway
Target(s)	Beta-2 adrenergic receptor	Target Info	Modulator	[533154]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Salivary secretion
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 544547	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000105)
Ref 533154	Broxaterol, a new beta 2-adrenoceptor agonist compared to salbutamol in asthmatics, oral and inhalation treatment. Respiration. 1989;55 Suppl 2:15-9.

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