Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0OS8C
|
||||
| Former ID |
DIB009617
|
||||
| Drug Name |
NCX-1015
|
||||
| Synonyms |
Nitroprednisolone; NCX-1004; NCX-1016; NO-prednisolone
|
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| Indication | Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] | Phase 1 | [1] | ||
| Company |
NicOx SA
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
[C@]12([C@@](C(=O)COC(=O)c3ccc(CO[N+](=O)[O-])cc3)(CC[C<br />@H]1[C@H]1[C@@H]([C@@]3(C(=CC(=O)C=C3)CC1)C)[C@H](C2)O)<br />O)C
|
||||
| CAS Number |
CAS 327610-87-7
|
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| Target and Pathway | |||||
| Target(s) | Glucocorticoid receptor | Target Info | Modulator | [1] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| TCR Signaling Pathway | |||||
| Pathway Interaction Database | Regulation of nuclear SMAD2/3 signaling | ||||
| Signaling events mediated by HDAC Class II | |||||
| FOXA2 and FOXA3 transcription factor networks | |||||
| Glucocorticoid receptor regulatory network | |||||
| Regulation of Androgen receptor activity | |||||
| AP-1 transcription factor network | |||||
| Reactome | BMAL1:CLOCK,NPAS2 activates circadian gene expression | ||||
| WikiPathways | Serotonin Receptor 4/6/7 and NR3C Signaling | ||||
| SIDS Susceptibility Pathways | |||||
| Nuclear Receptors Meta-Pathway | |||||
| Endoderm Differentiation | |||||
| Hair Follicle Development: Cytodifferentiation (Part 3 of 3) | |||||
| Adipogenesis | |||||
| Circadian Clock | |||||
| Nuclear Receptors | |||||
| References | |||||
| REF 1 | Glucocorticoid receptor nitration leads to enhanced anti-inflammatory effects of novel steroid ligands. J Immunol. 2003 Sep 15;171(6):3245-52. | ||||
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