Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0OW4A
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| Former ID |
DIB010243
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| Drug Name |
PD-145065
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| Synonyms |
N-Acetyl-2-D-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)glycyl-L-leucyl-L-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Phase 2 | [533860] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C52H67N7O10
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| Canonical SMILES |
CCC(C)C(C(=O)NC(C(C)CC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)<br />O)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(C3C4=CC=CC=C4C<br />CC5=CC=CC=C35)NC(=O)C
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| InChI |
1S/C52H67N7O10/c1-8-29(5)44(49(65)57-41(52(68)69)25-34-27-53-38-21-15-14-18-35(34)38)59-50(66)45(30(6)9-2)58-48(64)40(26-42(61)62)55-47(63)39(24-28(3)4)56-51(67)46(54-31(7)60)43-36-19-12-10-16-32(36)22-23-33-17-11-13-20-37(33)43/h10-21,27-30,39-41,43-46,53H,8-9,22-26H2,1-7H3,(H,54,60)(H,55,63)(H,56,67)(H,57,65)(H,58,64)(H,59,66)(H,61,62)(H,68,69)/t29-,30-,39-,40-,41-,44-,45-,46+/m0/s1
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| InChIKey |
HRAQSWKGRRUBDJ-OMUAVVNCSA-N
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Endothelin-1 receptor | Target Info | Modulator | [533860] | |
| Endothelin B receptor | Target Info | Modulator | [533860] | ||
| NetPath Pathway | IL4 Signaling Pathway | ||||
| PANTHER Pathway | Endothelin signaling pathwayP00019:Endothelin signaling pathway | ||||
| Pathway Interaction Database | Endothelins | ||||
| EGFR-dependent Endothelin signaling eventsendothelinpathway:Endothelins | |||||
| Arf6 trafficking events | |||||
| References | |||||
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