Drug General Information
Drug ID	D0P2VP
Former ID	DNC013342
Drug Name	(2S,1'R,2'S)-2-(2'-phosphonocyclopropyl)glycine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528723]
Structure		Download 2D MOL 3D MOL
Formula	C5H10NO5P
Canonical SMILES	C1C(C1P(=O)(O)O)C(C(=O)O)N
InChI	1S/C5H10NO5P/c6-4(5(7)8)2-1-3(2)12(9,10)11/h2-4H,1,6H2,(H,7,8)(H2,9,10,11)/t2-,3-,4?/m0/s1
InChIKey	KZOMBNQLBSHMFV-LPGMDIISSA-N
PubChem Compound ID	11708219
Target and Pathway
Target(s)	Metabotropic glutamate receptor 4	Target Info	Inhibitor	[528723]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Glutamatergic synapse
	Taste transduction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Metabotropic glutamate receptor group III pathway
Reactome	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways	GPCRs, Class C Metabotropic glutamate, pheromone
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528723	Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.
Ref 528723	Bioorg Med Chem. 2007 May 1;15(9):3161-70. Epub 2007 Feb 22.Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.

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