Drug General Information
Drug ID	D0P3FZ
Former ID	DNC012930
Drug Name	5-(piperidin-4-yl)isothiazol-3-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528034]
Structure		Download 2D MOL 3D MOL
Formula	C8H12N2OS
Canonical SMILES	C1CNCCC1C2=CC(=O)NS2
InChI	1S/C8H12N2OS/c11-8-5-7(12-10-8)6-1-3-9-4-2-6/h5-6,9H,1-4H2,(H,10,11)
InChIKey	WUINUICOEAZPLK-UHFFFAOYSA-N
PubChem Compound ID	10035301
Target and Pathway
Target(s)	Gamma-aminobutyric acid receptor	Target Info	Inhibitor	[528034]
	Gamma-aminobutyric acid receptor subunit gamma-2	Target Info	Inhibitor	[528034]
	Gamma-aminobutyric acid receptor subunit alpha-1	Target Info	Inhibitor	[528034]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Retrograde endocannabinoid signaling
	GABAergic synapse
	Morphine addiction
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
Reactome	Ligand-gated ion channel transport
	GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
	GABA A receptor activation
WikiPathways	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Iron uptake and transportWP706:SIDS Susceptibility Pathways
	Iron uptake and transport
References
Ref 528034	J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.
Ref 528034	J Med Chem. 2006 Feb 23;49(4):1388-96.Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.

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