Drug Information

Drug General Information
Drug ID
D0P3SJ
Former ID
DIB014362
Drug Name
XP-21279
Synonyms
Levodopa transported prodrug (Parkinson's disease), XenoPort; L-dopa transported prodrug (Parkinson's disease), XenoPort
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Phase 2 [523123]
Company
Xenoport
Structure
Download
2D MOL

3D MOL
Canonical SMILES
c1c(c(cc(c1)C[C@H](N)C(=O)OC[C@H](OC(=O)c1ccccc1)C)O)O.<br />CS(=O)(=O)O
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Agonist [532587]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
References
Ref 523123ClinicalTrials.gov (NCT01171313) A Efficacy, Safety and Pharmacokinetic Study of XP21279 and Sinemet in Parkinson's Disease Subjects. U.S. National Institutes of Health.
Ref 532587Double-blind study of the actively transported levodopa prodrug XP21279 in Parkinson's disease. Mov Disord. 2014 Jan;29(1):75-82.

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