Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P3TX
|
||||
| Former ID |
DAP000473
|
||||
| Drug Name |
Abciximab
|
||||
| Synonyms |
ReoPro (TN)
|
||||
| Drug Type |
Monoclonal antibody
|
||||
| Therapeutic Class |
Anticoagulants
|
||||
| Company |
Eli Lilly
|
||||
| Formula |
C6462H9964N1690O2049S48
|
||||
| CAS Number |
CAS 143653-53-6
|
||||
| SuperDrug ATC ID |
B01AC13
|
||||
| Target and Pathway | |||||
| Target(s) | Glycoprotein IIb/IIIa receptor | Target Info | Modulator | [556264] | |
| Reactome | Platelet degranulation | ||||
| Elastic fibre formation | |||||
| PECAM1 interactions | |||||
| Molecules associated with elastic fibres | |||||
| Integrin cell surface interactions | |||||
| Syndecan interactions | |||||
| ECM proteoglycans | |||||
| Integrin alphaIIb beta3 signaling | |||||
| GRB2:SOS provides linkage to MAPK signaling for Integrins | |||||
| p130Cas linkage to MAPK signaling for integrins | |||||
| VEGFA-VEGFR2 Pathway | |||||
| MAP2K and MAPK activation | |||||
| References | |||||
| Ref 536373 | Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs. 2007 Mar;12(1):97-112. | ||||
| Ref 541704 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6584). | ||||
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