Drug General Information
Drug ID
D0P4VI
Former ID
DIB019182
Drug Name
compound 1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532762]
Formula
C11H10N2O3S
InChI
InChI=1S/C11H10N2O3S/c1-2-16-11(15)8-9(14)13-10(17-8)7-3-5-12-6-4-7/h3-6,14H,2H2,1H3
InChIKey
SHVRAFGUKKOKIO-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) mitogen-activated protein kinase kinase kinase 19 Target Info Inhibitor [532762]
CDC7 protein kinase Target Info Inhibitor [532762]
TAO kinase 3 Target Info Inhibitor [532762]
Cell division protein kinase 8 Target Info Inhibitor [532762]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
WikiPathways Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Transcriptional Regulation of White Adipocyte Differentiation
Signaling by NOTCH1
SREBP signalling
Generic Transcription Pathway
References
Ref 532762Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82.
Ref 532762Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem. 2014 Jun 10;80:364-82.

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