Drug Information

Drug General Information
Drug ID
D0P4YG
Former ID
DNC000999
Drug Name
NBI-27914
Drug Type
Small molecular drug
Indication Depression [ICD9: 311; ICD10:F30-F39] Investigative [540450]
Structure
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2D MOL

3D MOL
Formula
C18H20Cl4N4
InChI
InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
InChIKey
KNADXBVKFAUMCR-UHFFFAOYSA-N
CAS Number
CAS 184241-44-9
PubChem Compound ID
176157
PubChem Substance ID
5916225, 7980096, 10258352, 11111536, 11114145, 14930153, 17405056, 24278425, 33499833, 46500411, 47276706, 50069830, 50104903, 50104904, 53777599, 53788663, 53801052, 57395288, 80947329, 85231154, 85788155, 90340601, 92304048, 103225612, 103950895, 104425366, 121361191, 124749758, 124799473, 124880882, 124880883, 134339939, 134340268, 135154099, 135298261, 162248258, 163564447, 178126277, 179235782
Target and Pathway
Target(s) Corticotropin releasing factor receptor 1 Target Info Antagonist [536307]
KEGG Pathway Neuroactive ligand-receptor interaction
Long-term depression
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Cortocotropin releasing factor receptor signaling pathway
Reactome Class B/2 (Secretin family receptors)
G alpha (s) signalling events
WikiPathways GPCRs, Class B Secretin-like
Myometrial Relaxation and Contraction Pathways
Corticotropin-releasing hormone
GPCR ligand binding
GPCR downstream signaling
References
Ref 540450(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3512).
Ref 536307A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68.

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