Drug Information

Drug General Information
Drug ID
D0P5OF
Former ID
DNC012430
Drug Name
7-Methoxy-1H-indazole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526052]
Structure
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2D MOL

3D MOL
Formula
C8H8N2O
Canonical SMILES
COC1=CC=CC2=C1NN=C2
InChI
1S/C8H8N2O/c1-11-7-4-2-3-6-5-9-10-8(6)7/h2-5H,1H3,(H,9,10)
InChIKey
QCBANHQTMCETBI-UHFFFAOYSA-N
PubChem Compound ID
10441839
Target and Pathway
Target(s) Nitric-oxide synthase, brain Target Info Inhibitor [526052]
BioCyc Pathway Citrulline-nitric oxide cycle
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
Phagosome
Circadian entrainment
Long-term depression
Salivary secretion
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
NetPath Pathway EGFR1 Signaling Pathway
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Arginine and Proline Metabolism
Reactome ROS production in response to bacteria
Nitric oxide stimulates guanylate cyclase
WikiPathways Monoamine Transport
Myometrial Relaxation and Contraction Pathways
Amyotrophic lateral sclerosis (ALS)
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Spinal Cord Injury
Alzheimers Disease
Effects of Nitric Oxide
Serotonin Transporter Activity
References
Ref 526052Bioorg Med Chem Lett. 2001 May 7;11(9):1153-6.Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
Ref 526052Bioorg Med Chem Lett. 2001 May 7;11(9):1153-6.Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.

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