Drug General Information
Drug ID	D0P5TR
Former ID	DIB005891
Drug Name	CGP-28014
Drug Type	Small molecular drug
Indication	Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32]		Phase 2	[530430]
Company	Novartis AG
Structure		Download 2D MOL 3D MOL
Formula	C12H19N3O
Canonical SMILES	[nH]1c(/N=C/N(CCC)CCC)cccc1=O
CAS Number	CAS 111757-17-6
PubChem Compound ID	9577272
Target and Pathway
Target(s)	Catechol-O-methyl-transferase	Target Info	Modulator	[530430]
BioCyc Pathway	L-dopa degradation
	Dopamine degradation
	Noradrenaline and adrenaline degradation
KEGG Pathway	Steroid hormone biosynthesis
	Tyrosine metabolism
	Metabolic pathways
	Dopaminergic synapse
PANTHER Pathway	Adrenaline and noradrenaline biosynthesis
	Dopamine receptor mediated signaling pathway
PathWhiz Pathway	Tyrosine Metabolism
WikiPathways	Methylation Pathways
	Metapathway biotransformation
	Estrogen metabolism
	Biogenic Amine Synthesis
	Dopamine metabolism
	Phase II conjugation
	Neurotransmitter Clearance In The Synaptic Cleft
References
Ref 530430	CGP 28014, a new inhibitor of cerebral catechol-O-methylation with a non-catechol structure. Naunyn Schmiedebergs Arch Pharmacol. 1990 Sep;342(3):305-11.
Ref 530430	CGP 28014, a new inhibitor of cerebral catechol-O-methylation with a non-catechol structure. Naunyn Schmiedebergs Arch Pharmacol. 1990 Sep;342(3):305-11.

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