TTD | Drug: D0P5UE

Drug General Information
Drug ID	D0P5UE
Former ID	DIB004469
Drug Name	50-235
Synonyms	Myriceric acid A
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[545617]
Company	Shionogi & Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	[C@@]12([C@]3([C@@H]([C@@]4([C@@H](CC3)C(C(=O)CC4)(C)C)<br />C)CC=C1[C@H]1[C@@](CC2)(CCC(C1)(C)C)C(=O)O)C)COC(=O)/C=<br />C/c1cc(c(cc1)O)O
CAS Number	CAS 142877-49-4
Target and Pathway
Target(s)	Endothelin-1 receptor	Target Info	Modulator	[533968]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Renin secretion
	Pathways in cancer
NetPath Pathway	IL4 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
Pathway Interaction Database	Endothelins
Pathway Interaction Database	EGFR-dependent Endothelin signaling events
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 545617	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003913)
Ref 533968	Structure-activity relationships of an endothelin ETA receptor antagonist, 50-235, and its derivatives. Eur J Pharmacol. 1993 Oct 15;247(2):219-21.

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Drug Information