Drug Information

Drug General Information
Drug ID
D0P5VJ
Former ID
DNC008781
Drug Name
KM-233
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529515]
Structure
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2D MOL

3D MOL
Formula
C25H30O2
Canonical SMILES
CC1=CCC2C(C1)C3=C(C=C(C=C3O)C(C)(C)C4=CC=CC=C4)OC2(C)C
InChI
1S/C25H30O2/c1-16-11-12-20-19(13-16)23-21(26)14-18(15-22(23)27-25(20,4)5)24(2,3)17-9-7-6-8-10-17/h6-11,14-15,19-20,26H,12-13H2,1-5H3
InChIKey
GZYXCXRHVALIJD-UHFFFAOYSA-N
PubChem Compound ID
71308228
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [529515]
Cannabinoid receptor 1 Target Info Inhibitor [529515]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 529515Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. Epub 2008 May 20.Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs.
Ref 529515Bioorg Med Chem. 2008 Jul 1;16(13):6489-500. Epub 2008 May 20.Exploring the substituent effects on a novel series of C1'-dimethyl-aryl Delta8-tetrahydrocannabinol analogs.

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