Drug Information

Drug General Information
Drug ID
D0P8TX
Former ID
DIB018390
Drug Name
[3H]ramatroban
Synonyms
[3H]BAY u3405; [3H]Bay u 3405; [3H]baynas
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539211]
Structure
Download
2D MOL
Formula
C21H21FN2O4S
InChI
InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
InChIKey
LDXDSHIEDAPSSA-OAHLLOKOSA-N
PubChem Compound ID
123879
PubChem Substance ID
7848191, 7980465, 10240891, 12014153, 14806727, 14904588, 29304055, 50064212, 50112772, 53788138, 57340633, 79986756, 92719267, 93310921, 103444835, 104048051, 104419548, 118046311, 126592924, 126628292, 126650406, 126666119, 128475209, 134338974, 135079755, 135650884, 135651196, 135698277, 136910242, 137923239, 144206069, 152106038, 152164410, 152246312, 162248522, 163305476, 163392631, 170465980, 174006902, 179149649, 186021988, 187072440, 196111770, 198937833, 204379957, 208265308, 210279843, 210282166, 223554817, 223655760
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [527831]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539211(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1910).
Ref 527831CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses. Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7. Epub 2005 Oct 27.

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