Drug General Information
Drug ID	D0P9ED
Former ID	DNC007889
Drug Name	CMI-489
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529145]
Structure		Download 2D MOL 3D MOL
Formula	C12H15ClN2
Canonical SMILES	CN1C2CCC1C(C2)C3=CN=C(C=C3)Cl
InChI	1S/C12H15ClN2/c1-15-9-3-4-11(15)10(6-9)8-2-5-12(13)14-7-8/h2,5,7,9-11H,3-4,6H2,1H3
InChIKey	HLNPMOXPJPCMLY-UHFFFAOYSA-N
PubChem Compound ID	11601009
Target and Pathway
Target(s)	Neuronal acetylcholine receptor protein, alpha-4 chain	Target Info	Inhibitor	[529145]
	Neuronal acetylcholine receptor protein, beta-2 chain	Target Info	Inhibitor	[529145]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
	Nicotine addiction
PANTHER Pathway	Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathwayP00044:Nicotinic acetylcholine receptor signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
	Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors
	Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways	SIDS Susceptibility Pathways
	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
	Nicotine Activity on Dopaminergic NeuronsWP706:SIDS Susceptibility Pathways
	Nicotine Activity on Dopaminergic Neurons
References
Ref 529145	J Med Chem. 2007 Dec 13;50(25):6383-91. Epub 2007 Nov 10.Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.
Ref 529145	J Med Chem. 2007 Dec 13;50(25):6383-91. Epub 2007 Nov 10.Synthesis and nicotinic acetylcholine receptor binding properties of bridged and fused ring analogues of epibatidine.

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