Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P9FT
|
||||
| Former ID |
DIB011542
|
||||
| Drug Name |
REC-15-2739
|
||||
| Synonyms |
SB-216469; REC-15-2869; REC-15-3011; REC-22/009
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Prostate disease [ICD10:N42.9] | Discontinued in Phase 2 | [1] | ||
| Company |
Recordati SpA
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C31H33N3O4
|
||||
| Canonical SMILES |
c12oc(c(c(=O)c1cccc2C(=O)NCCCN1CCN(c2c(OC)cccc2)CC1)C)c<br />1ccccc1
|
||||
| CAS Number |
CAS 152735-23-4
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Alpha-1D adrenergic receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| cGMP-PKG signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Salivary secretion | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Reactome | Adrenoceptors | ||||
| G alpha (q) signalling events | |||||
| G alpha (12/13) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003537) | ||||
| REF 2 | Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1237-46. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.