Drug Information

Drug General Information
Drug ID
D0P9KL
Former ID
DCL000655
Drug Name
TAK-683
Drug Type
Small molecular drug
Indication Prostate cancer [ICD9: 185; ICD10:C61] Discontinued in Phase 1 [548739]
Prostate cancer [ICD9: 185; ICD10:C61] Terminated [548739]
Company
Takeda
Structure
Download
2D MOL

3D MOL
Formula
C22H35NO3
Canonical SMILES
CCCCCC=CCC(C=CC1=NC(=CC=C1)CC(CCCCO)O)O
InChI
1S/C22H35NO3/c1-2-3-4-5-6-7-13-21(25)16-15-19-11-10-12-20(23-19)18-22(26)14-8-9-17-24/h6-7,10-12,15-16,21-22,24-26H,2-5,8-9,13-14,17-18H2,1H3/b7-6-,16-15+/t21-,22+/m1/s1
InChIKey
JNBOAUIJLDEICX-LJCAKPRGSA-N
PubChem Compound ID
6449854
PubChem Substance ID
14901458, 43041026, 53787219, 57369980, 71851854, 75559202, 114582771, 134339177, 134340656, 135227803, 178100358, 184526518, 184590068, 228062396
Target and Pathway
Target(s) G-protein coupled receptor 54 Target Info Agonist [551155], [551717]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 548739Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028256)
Ref 551155The efficacy and tolerability of two novel H(1)/H(3) receptor antagonists in seasonal allergic rhinitis. Int Arch Allergy Immunol. 2012;158(1):84-98.
Ref 551717Clinical pipeline report, company report or official report of Takeda (2009).

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