TTD | Drug: D0PB6B

Drug General Information
Drug ID	D0PB6B
Former ID	DIB019746
Drug Name	dimethylhistaprodifen
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538716]
Structure		Download 2D MOL
Formula	C22H27N3
InChI	InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24)
InChIKey	GNBOIGBQIBQOIA-UHFFFAOYSA-N
PubChem Compound ID	10042467
PubChem Substance ID	15025569, 44159524, 48105230, 48329092, 78563243, 92729719, 103172036, 135650187, 136352270
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Agonist	[526569]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538716	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1203).
Ref 526569	Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor. J Pharmacol Exp Ther. 2003 Jun;305(3):1104-15. Epub 2003 Mar 6.

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Drug Information