| Drug General Information |
| Drug ID |
D0PC2C
|
| Former ID |
DNC011820
|
| Drug Name |
3-Ethyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-6-ol
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H17NO
|
| Canonical SMILES |
CCN1CCC2=C(CC1)C(=CC=C2)O
|
| InChI |
1S/C12H17NO/c1-2-13-8-6-10-4-3-5-12(14)11(10)7-9-13/h3-5,14H,2,6-9H2,1H3
|
| InChIKey |
HTCXSPINZBVTNI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
cAMP signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Serotonergic synapsehsa04015:Rap1 signaling pathway
|
|
Gap junction
|
|
Dopaminergic synapse
|
|
Parkinson's disease
|
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Cocaine addiction
|
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Alcoholism
|
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathway
|
|
Reactome
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Serotonin receptors
|
|
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
|
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G alpha (i) signalling events
|
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
|
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
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GPCR ligand binding
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GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
|
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Genes and (Common) Pathways Underlying Drug Addiction
|
|
GPCR downstream signaling
|
|
Nicotine Activity on Dopaminergic Neurons
|
| References |
| REF 1 | J Med Chem. 1992 Oct 30;35(22):3984-90.6-Hydroxy-3-n-propyl-2,3,4,5-tetrahydro-1H-3-benzazepine and analogs: new centrally acting 5-HT1A receptor agonists. |
|---|
