Drug Information

Drug General Information
Drug ID
D0PC5A
Former ID
DNC009879
Drug Name
VER-156084
Drug Type
Small molecular drug
Indication Neuropathic pain [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Investigative [530200]
Structure
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2D MOL

3D MOL
Formula
C21H23Cl2N3O2
Canonical SMILES
C1CCN(CC1)C(=O)N2CC(C2)OC(C3=CC=C(C=C3)Cl)C4=C(N=CC=C4)<br />Cl
InChI
1S/C21H23Cl2N3O2/c22-16-8-6-15(7-9-16)19(18-5-4-10-24-20(18)23)28-17-13-26(14-17)21(27)25-11-2-1-3-12-25/h4-10,17,19H,1-3,11-14H2/t19-/m0/s1
InChIKey
QEKKZTBXSULKCC-IBGZPJMESA-N
PubChem Compound ID
44243144
Target and Pathway
Target(s) Cannabinoid receptor 2 Target Info Inhibitor [530200]
Cannabinoid receptor 1 Target Info Inhibitor [530200]
Fatty-acid amide hydrolase Target Info Inhibitor [530200]
BioCyc Pathway Anandamide degradation
KEGG Pathway Neuroactive ligand-receptor interactionhsa04015:Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04723:Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signalingP05728:Anandamide degradation
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
BDNF signaling pathway
GPCR downstream signaling
GPCRs, Other
References
Ref 530200Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. Epub 2009 May 29.Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.
Ref 530200Bioorg Med Chem Lett. 2009 Aug 1;19(15):4241-4. Epub 2009 May 29.Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas.

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