Drug General Information
Drug ID
D0PE2L
Former ID
DNCL001576
Drug Name
GSK2402968
Indication Duchenne muscular dystrophy [ICD10:G71.0] Phase 3 [523702]
Company
GlaxoSmithKline; Prosensa
Target and Pathway
Target(s) mRNA of Dystrophin Target Info Modulator [523277], [532951]
KEGG Pathway Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
Viral myocarditis
NetPath Pathway IL4 Signaling Pathway
IL5 Signaling Pathway
Reactome Non-integrin membrane-ECM interactions
Striated Muscle Contraction
WikiPathways Striated Muscle Contraction
Ectoderm Differentiation
Extracellular matrix organization
Arrhythmogenic Right Ventricular Cardiomyopathy
Muscle contraction
References
Ref 523702ClinicalTrials.gov (NCT01480245) Open Label Study of GSK2402968 in Subjects With Duchenne Muscular Dystrophy. U.S. National Institutes of Health.
Ref 523277ClinicalTrials.gov (NCT01254019) A Clinical Study to Assess the Efficacy and Safety of GSK2402968 in Subjects With Duchenne Muscular Dystrophy. U.S. National Institutes of Health.
Ref 532951Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study. Lancet Neurol. 2014 Oct;13(10):987-96.

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