Drug Information

Drug General Information
Drug ID
D0PG0G
Former ID
DAP000151
Drug Name
Drotrecogin alfa
Synonyms
Xigris; Drotrecogin alfa (activated); Xigris (TN); Drotrecogin alfa (activated) (USAN)
Indication Severe sepsis; Cerebrovascular ischaemia [ICD9: 995.91, 434.91; ICD10:A40-A41, I61-I63] Approved [536361], [541868], [551871]
Therapeutic Class
Antisepsis Agents
Company
Eli Lilly
Formula
C1786H2779N509O519S29
CAS Number
CAS 60202-16-6
PubChem Substance ID
47205907
SuperDrug ATC ID
B01AD10
Target and Pathway
Target(s) Coagulation Factor VIIIa Target Info Inhibitor [537427]
Coagulation Factor Va Target Info Inhibitor [537427]
KEGG Pathway Complement and coagulation cascadeshsa04610:Complement and coagulation cascades
PANTHER Pathway Blood coagulation
PathWhiz Pathway CoagulationPW000562:Coagulation
Reactome Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ERR-HSA-114608:Platelet degranulation
Cargo concentration in the ER
WikiPathways Complement and Coagulation Cascades
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)WP558:Complement and Coagulation Cascades
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 541868(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6788).
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 537427Protein C in critical illness. Am J Health Syst Pharm. 2009 Jun 15;66(12):1089-96.

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