Drug General Information
Drug ID	D0PG0S
Former ID	DIB016093
Drug Name	CI-999
Synonyms	PD-138142-15
Indication	Arteriosclerosis [ICD9: 440; ICD10:I70]		Terminated	[546902]
Company	Warner-Lambert Co
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(cccc1C(C)C)C(C)C)OS(=O)(=O)[N-]C(=O)Oc1c(cccc1C(C)<br />C)C(C)C.[Na+]
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[534786]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 546902	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010990)
Ref 534786	Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett. 1998 Feb 3;8(3):289-94.

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