Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0PG0S
|
||||
| Former ID |
DIB016093
|
||||
| Drug Name |
CI-999
|
||||
| Synonyms |
PD-138142-15
|
||||
| Indication | Arteriosclerosis [ICD9: 440; ICD10:I70] | Terminated | [1] | ||
| Company |
Warner-Lambert Co
|
||||
| Structure |
|
Download2D MOL |
|||
| Canonical SMILES |
c1(c(cccc1C(C)C)C(C)C)OS(=O)(=O)[N-]C(=O)Oc1c(cccc1C(C)<br />C)C(C)C.[Na+]
|
||||
| Target and Pathway | |||||
| Target(s) | Liver carboxylesterase | Target Info | Inhibitor | [2] | |
| KEGG Pathway | Drug metabolism - other enzymes | ||||
| Metabolic pathways | |||||
| Pathway Interaction Database | E2F transcription factor network | ||||
| WikiPathways | NRF2 pathway | ||||
| Nuclear Receptors Meta-Pathway | |||||
| Heroin metabolism | |||||
| Irinotecan Pathway | |||||
| Fluoropyrimidine Activity | |||||
| Phase I biotransformations, non P450 | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010990) | ||||
| REF 2 | Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett. 1998 Feb 3;8(3):289-94. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.