TTD | Drug: D0PU5L

Drug General Information
Drug ID	D0PU5L
Former ID	DIB012793
Drug Name	Adaprolol maleate-SME
Synonyms	Adaprolol; Adaprolol maleate; CDDD-2803; HGP-2; Submicron Emulsion, Pharmos; Adaprolol maleate-SME, Pharmos
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Discontinued in Phase 2	[545496]
Company	Pharmos Corp
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C12(CC3CC(C1)CC(C2)C3)CCOC(=O)Cc1ccc(OCC(CNC(C)C)O)cc1.<br />C(=O)(/C=C\C(=O)O)O
Target and Pathway
Target(s)	Beta-3 adrenergic receptor	Target Info	Modulator	[534192]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Salivary secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PANTHER Pathway	Beta3 adrenergic receptor signaling pathway
Reactome	Adrenoceptors
Reactome	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545496	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003472)
Ref 534192	Synthesis and pharmacological activity of adaprolol enantiomers: a new soft drug for treating glaucoma. J Ocul Pharmacol Ther. 1996 Summer;12(2):115-22.

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Drug Information