Drug Information

Drug General Information
Drug ID
D0Q0OP
Former ID
DIB014981
Drug Name
CAB-2
Synonyms
MLN2222
Indication Coronary artery disease [ICD9: 410-414, 429.2; ICD10:I20-I25] Discontinued in Phase 1 [546768]
Company
Millennium Pharmaceuticals
Target and Pathway
Target(s) Complement Factor B Target Info Inhibitor [526294]
KEGG Pathway Complement and coagulation cascades
Staphylococcus aureus infection
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome Alternative complement activation
Activation of C3 and C5
Regulation of Complement cascade
WikiPathways Complement and Coagulation Cascades
Human Complement System
Complement cascade
References
Ref 546768Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010210)
Ref 526294A soluble chimeric inhibitor of C3 and C5 convertases, complement activation blocker-2, prolongs graft survival in pig-to-rhesus monkey heart transplantation. Xenotransplantation. 2002 Mar;9(2):125-34.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.