Drug Information

Drug General Information
Drug ID
D0Q1HF
Former ID
DIB018793
Drug Name
NCGC00167772-01
Synonyms
NCGC00167772-01; 10-DEBC
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527632]
Structure
Download
2D MOL
Formula
C20H25ClN2O
InChI
InChI=1S/C20H25ClN2O/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3
InChIKey
GYBXAGDWMCJZJK-UHFFFAOYSA-N
PubChem Compound ID
10521421
PubChem Substance ID
15547306, 22840519, 41902027, 50112909, 80088766, 138622295, 163322672, 172659520, 177748572, 178102545, 179694491, 228393810, 243649005
Target and Pathway
Target(s) Proto-oncogene pim-1 Target Info Inhibitor [543563]
KEGG Pathway Jak-STAT signaling pathway
MicroRNAs in cancer
Acute myeloid leukemia
NetPath Pathway IL9 Signaling Pathway
IL5 Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database GMCSF-mediated signaling events
Validated targets of C-MYC transcriptional activation
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL5-mediated signaling events
IL3-mediated signaling events
C-MYB transcription factor network
WikiPathways Ectoderm Differentiation
Hematopoietic Stem Cell Differentiation
References
Ref 527632Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J Biol Chem. 2005 Sep 9;280(36):31924-35. Epub 2005 Jul 11.
Ref 543563(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2158).

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