Drug Information

Drug General Information
Drug ID
D0Q2JS
Former ID
DIB002275
Drug Name
SB-282241
Synonyms
CCR2B antagonists, GlaxoSmithKline; SB-282241; SB-380732; MCP-1 antagonists, GlaxoSmithKline
Drug Type
Small molecular drug
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Terminated [526712], [542764]
Company
SmithKline Beecham Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C27H31Cl2N3O2
InChI
InChI=1S/C27H31Cl2N3O2/c28-24-7-4-19(16-25(24)29)5-9-27(34)30-12-2-1-3-13-32-14-10-20(11-15-32)23-18-31-26-8-6-21(33)17-22(23)26/h4-9,16-18,20,31,33H,1-3,10-15H2,(H,30,34)/b9-5+
InChIKey
QBRLVMQBZIFWTB-WEVVVXLNSA-N
PubChem Compound ID
10436045
PubChem Substance ID
15455848, 24448387, 40563704, 79170805, 85868354, 103235701, 103989697, 135651004, 180093032
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [550879]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 526712CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach. J Med Chem. 2003 Sep 11;46(19):4070-86.
Ref 542764(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 782).
Ref 550879Patent EP2727944 A1.

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