Drug Information

Drug General Information
Drug ID
D0Q3BG
Former ID
DIB009681
Drug Name
Gene therapy, IFN-b
Synonyms
Gene therapy (IFN-b)
Indication Glioblastoma multiforme [ICD9: 191; ICD10:C71] Phase 1 [529271]
Company
Nagoya University
Target and Pathway
Target(s) Interferon beta ligand Target Info Modulator [527290]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Osteoclast differentiation
Toll-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
Chagas disease (American trypanosomiasis)
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Herpes simplex infection
NetPath Pathway TNFalpha Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Reactome Oxidative Stress Induced Senescence
Interferon alpha/beta signaling
Regulation of IFNA signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Factors involved in megakaryocyte development and platelet production
WikiPathways Toll-like receptor signaling pathway
Type II interferon signaling (IFNG)
Senescence and Autophagy in Cancer
Cytokines and Inflammatory Response
EBV LMP1 signaling
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Interferon alpha/beta signaling
Regulation of toll-like receptor signaling pathway
Osteoclast Signaling
References
Ref 529271A phase I clinical trial of interferon-beta gene therapy for high-grade glioma: novel findings from gene expression profiling and autopsy. J Gene Med. 2008 Apr;10(4):329-39.
Ref 527290Interferon-beta gene therapy for cancer: basic research to clinical application. Cancer Sci. 2004 Nov;95(11):858-65.

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