Drug Information

Drug General Information
Drug ID
D0Q3NG
Former ID
DNC006661
Drug Name
N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528318]
Structure
Download
2D MOL

3D MOL
Formula
C10H12N4O2
Canonical SMILES
CCOC1=C(C(=CC(=N1)NC(=O)C)N)C#N
InChI
1S/C10H12N4O2/c1-3-16-10-7(5-11)8(12)4-9(14-10)13-6(2)15/h4H,3H2,1-2H3,(H3,12,13,14,15)
InChIKey
DXAJWOOLPAIVJG-UHFFFAOYSA-N
PubChem Compound ID
11715520
Target and Pathway
Target(s) Mitogen-activated protein kinase 10 Target Info Inhibitor [528237]
mRNA of human Jun-N-terminal kinase-2 (JNK2) Target Info Inhibitor [528237]
Mitogen-activated protein kinase 8 Target Info Inhibitor [528318]
KEGG Pathway MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
cAMP signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Protein processing in endoplasmic reticulum
Wnt signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Fc epsilon RI signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Dopaminergic synapse
Inflammatory mediator regulation of TRP channels
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Prolactin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Salmonella infection
Pertussis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Choline metabolism in cancerhsa04010:MAPK signaling pathway
T cell receptor signaling pathway
HTLV-I infection
Choline metabolism in cancer
NetPath Pathway IL5 Signaling Pathway
TNFalpha Signaling Pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Apoptosis signaling pathway
B cell activation
EGF receptor signaling pathway
FAS signaling pathway
FGF signaling pathway
Integrin signalling pathway
Interferon-gamma signaling pathway
Parkinson disease
TGF-beta signaling pathway
Ras Pathway
CCKR signaling map STP00003:Alzheimer disease-amyloid secretase pathway
Huntington disease
Oxidative stress response
T cell activation
Toll receptor signaling pathway
Angiogenesis
PDGF signaling pathway
CCKR signaling map ST
Pathway Interaction Database Noncanonical Wnt signaling pathway
CD40/CD40L signaling
FAS (CD95) signaling pathway
Glucocorticoid receptor regulatory network
FoxO family signaling
p75(NTR)-mediated signaling
ErbB2/ErbB3 signaling events
PDGFR-beta signaling pathway
Nephrin/Neph1 signaling in the kidney podocytewnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
CDC42 signaling events
Role of Calcineurin-dependent NFAT signaling in lymphocytes
IL2-mediated signaling events
Rapid glucocorticoid signaling
ErbB1 downstream signaling
ATF-2 transcription factor network
Nephrin/Neph1 signaling in the kidney podocyte
p53 pathway
Downstream signaling in na&#xef
RAC1 signaling pathway
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinase
Glypican 3 network
IL12 signaling mediated by STAT4fcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
RhoA signaling pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Osteopontin-mediated events
Reelin signaling pathway
TRAIL signaling pathway
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
IL1-mediated signaling events
Ceramide signaling pathway
Regulation of Androgen receptor activity
JNK signaling in the CD4+ TCR pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Retinoic acid receptors-mediated signaling
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
Syndecan-2-mediated signaling events
Ephrin B reverse signaling
N-cadherin signaling events
S1P2 pathway
IL12 signaling mediated by STAT4
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Reactome Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factorsR-HSA-2559580:Oxidative Stress Induced Senescence
Activation of the AP-1 family of transcription factorsR-HSA-193648:NRAGE signals death through JNK
NRIF signals cell death from the nucleus
DSCAM interactions
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
WikiPathways Toll-like receptor signaling pathway
DNA Damage Response (only ATM dependent)
G13 Signaling Pathway
Insulin Signaling
Wnt Signaling Pathway
MAPK Cascade
Oxidative Stress
Wnt Signaling Pathway and Pluripotency
Apoptosis Modulation by HSP70
MAPK Signaling Pathway
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Apoptosis
BDNF signaling pathway
Integrin-mediated Cell Adhesion
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
TCR Signaling Pathway
TGF Beta Signaling Pathway
EGF/EGFR Signaling Pathway
TGF beta Signaling Pathway
Wnt Signaling Pathway Netpath
JAK/STAT
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Corticotropin-releasing hormone
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
TWEAK Signaling Pathway
RANKL/RANK Signaling Pathway
IL-1 signaling pathway
ErbB Signaling Pathway
FAS pathway and Stress induction of HSP regulation
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
Transcriptional activation by NRF2
NLR Proteins
IL-3 Signaling Pathway
Cardiac Hypertrophic Response
EBV LMP1 signaling
PDGF Pathway
Nanoparticle triggered regulated necrosis
Prostate Cancer
Leptin signaling pathway
Signalling by NGF
Intrinsic Pathway for Apoptosis
DSCAM interactions
Apoptosis Modulation and Signaling
Type II diabetes mellitus
MicroRNAs in cardiomyocyte hypertrophy
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteoclast Signaling
References
Ref 528318J Med Chem. 2006 Jul 27;49(15):4455-8.Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
Ref 528237J Med Chem. 2006 Jun 15;49(12):3563-80.Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
Ref 528318J Med Chem. 2006 Jul 27;49(15):4455-8.Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.

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