Drug Information

Drug General Information
Drug ID
D0Q3UL
Former ID
DPR000090
Drug Name
PD-160170
Synonyms
NCGC00092332-01; BRD-K12079898-001-01-8; 5-nitro-6-(2-propan-2-ylphenyl)sulfonyl-quinolin-8-amine
Drug Type
Small molecular drug
Indication Hypertension; Obesity; Heart disease [ICD9: 278, 390-429; ICD10:E66, I00-I52] Preclinical [536122]
Company
Parke CDavis
Structure
Download
2D MOL

3D MOL
Formula
C18H17N3O4S
Canonical SMILES
CC(C)C1=CC=CC=C1S(=O)(=O)C2=C(C3=C(C(=C2)N)N=CC=C3)[N+]<br />(=O)[O-]
InChI
1S/C18H17N3O4S/c1-11(2)12-6-3-4-8-15(12)26(24,25)16-10-14(19)17-13(7-5-9-20-17)18(16)21(22)23/h3-11H,19H2,1-2H3
InChIKey
YUVNGBZROXQYQH-UHFFFAOYSA-N
CAS Number
CAS 181468-88-2
PubChem Compound ID
9820766
PubChem Substance ID
14779594, 24124336, 26753229, 44856726, 78995324, 85788693, 91746396, 103237292, 104129098, 125667600, 129851456, 134339533, 135698231, 143125196, 162023106, 163122127, 164759627, 172849967, 184538766, 202559042, 204362265, 226946512, 241375818, 252156353, 252374246
Target and Pathway
Target(s) Neuropeptide Y receptor type 1 Target Info Antagonist [536122]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway FSH Signaling Pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
Ref 536122Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.

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