TTD | Drug: D0Q3WC

Drug General Information
Drug ID	D0Q3WC
Former ID	DNC006470
Drug Name	1-methoxy-3-(3-(pyridin-4-yl)-1H-indol-6-yl)urea
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528041]
Structure		Download 2D MOL 3D MOL
Formula	C15H14N4O2
Canonical SMILES	CONC(=O)NC1=CC2=C(C=C1)C(=CN2)C3=CC=NC=C3
InChI	1S/C15H14N4O2/c1-21-19-15(20)18-11-2-3-12-13(9-17-14(12)8-11)10-4-6-16-7-5-10/h2-9,17H,1H3,(H2,18,19,20)
InChIKey	XYNMCCVGHHUPIU-UHFFFAOYSA-N
PubChem Compound ID	44410473
Target and Pathway
Target(s)	Inosine-5'-monophosphate dehydrogenase 2	Target Info	Inhibitor	[528041]
BioCyc Pathway	Purine nucleotides degradation
	Urate biosynthesis/inosine 5'-phosphate degradation
	Guanosine nucleotides de novo biosynthesis
	Superpathway of purine nucleotide salvage
	Purine nucleotides de novo biosynthesis
	Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway	Purine metabolism
	Drug metabolism - other enzymes
	Metabolic pathways
PANTHER Pathway	De novo purine biosynthesis
Reactome	Purine ribonucleoside monophosphate biosynthesis
References
Ref 528041	Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. Epub 2006 Feb 17.Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Ref 528041	Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. Epub 2006 Feb 17.Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.

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Drug Information