Drug Information

Drug General Information
Drug ID
D0Q4DT
Former ID
DIB009275
Drug Name
HuMax-TAC
Synonyms
Anti-IL-2R antibody, Genmab/Merck Serono
Drug Type
Antibody
Indication Autoimmune diabetes [ICD10:E08-E13] Terminated [547655]
Company
Genmab A/S
Target and Pathway
Target(s) Interleukin-2 receptor alpha chain Target Info [525375]
KEGG Pathway Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Measles
HTLV-I infection
NetPath Pathway IL5 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
TNFalpha Signaling Pathway
Leptin Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Arf6 trafficking events
SHP2 signaling
IL2-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Calcium signaling in the CD4+ TCR pathway
Downstream signaling in na&#xef
IL12 signaling mediated by STAT4
Reactome GPVI-mediated activation cascade
G beta:gamma signalling through PI3Kgamma
Interleukin-2 signaling
RAF/MAP kinase cascade
Interleukin receptor SHC signaling
WikiPathways IL-2 Signaling Pathway
Inflammatory Response Pathway
Interleukin-2 signaling
Allograft Rejection
TSLP Signaling Pathway
IL-7 Signaling Pathway
Interleukin-3, 5 and GM-CSF signaling
References
Ref 547655Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018175)
Ref 525375Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012 Mar;32(2):254-93. doi: 10.1002/med.20212. Epub 2010 Jun 13.

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