Drug Information

Drug General Information
Drug ID
D0Q4OW
Former ID
DNCL002697
Drug Name
Pixantrone
Synonyms
Pixuvri (TN)
Drug Type
Small molecular drug
Indication Diffuse large B-cell lymphoma; Follicular lymphoma; Multiple scierosis [ICD9: 200.0, 202.0, 202.8, 340; ICD10:C81-C86, C82, C83.3, C85.1, G35] Phase 3 [521605], [542546]
Company
Cell Therapeutics
Structure
Download
2D MOL

3D MOL
Formula
C17H19N5O2
InChI
InChI=1S/C17H19N5O2/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24/h1-3,6,9,21-22H,4-5,7-8,18-19H2
InChIKey
PEZPMAYDXJQYRV-UHFFFAOYSA-N
PubChem Compound ID
134019
PubChem Substance ID
10243500, 14801640, 29311813, 47207191, 50268815, 57344765, 103424027, 104381156, 109692982, 123393022, 125822854, 126644882, 126681869, 128906544, 131299096, 135089360, 137002674, 141851778, 162172211, 162223317, 164764466, 164779938, 175437690, 179323415, 187051845, 198945891, 198993081, 210274945, 210280583, 223659404, 224997157, 225144373, 226399140, 241035957, 251916789, 251918028, 251971287, 252216086, 252448477
SuperDrug ATC ID
L01DB11
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [1572591]
References
Ref 521605ClinicalTrials.gov (NCT00088530) BBR 2778 for Relapsed, Aggressive Non-Hodgkin's Lymphoma (NHL). U.S. National Institutes of Health.
Ref 542546(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7544).
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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