Drug Information

Drug General Information
Drug ID
D0Q5YF
Former ID
DCL000088
Drug Name
Cipralisant
Synonyms
Cipralisant [INN]; 5-[(1R,2R)-2-(5,5-dimethylhex-1-ynyl)cyclopropyl]-1H-imidazole
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Discontinued in Phase 2 [536225], [538758]
Company
Gliatech
Structure
Download
2D MOL

3D MOL
Formula
C14H20N2
InChI
InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m1/s1
InChIKey
CVKJAXCQPFOAIN-VXGBXAGGSA-N
PubChem Compound ID
6450823
PubChem Substance ID
15121332, 43041867, 50075023, 51095645, 103184440, 103967832, 114525948, 127683545, 135198897, 135650808, 137147461, 139979947, 198977663, 225062545, 232727350
Target and Pathway
Target(s) Histamine H3 receptor Target Info Binder [536066]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 536225Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36.
Ref 538758(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1244).
Ref 536066G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations. J Pharmacol Exp Ther. 2005 Jul;314(1):271-81. Epub 2005 Apr 8.

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