TTD | Drug: D0Q7BG

Drug General Information
Drug ID	D0Q7BG
Former ID	DIB018835
Drug Name	AMG-837
Synonyms	AMG 837; AMG837
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541619]
Structure		Download 2D MOL
Formula	C26H21F3O3
InChI	InChI=1S/C26H21F3O3/c1-2-4-21(16-25(30)31)20-9-13-24(14-10-20)32-17-18-5-3-6-22(15-18)19-7-11-23(12-8-19)26(27,28)29/h3,5-15,21H,16-17H2,1H3,(H,30,31)/t21-/m0/s1
InChIKey	ZOPNBMMVVZRSGH-NRFANRHFSA-N
PubChem Compound ID	46854655
PubChem Substance ID	123047982, 134460417, 136966752, 140424369, 163408761, 163847993, 172860683, 178103099, 189053049, 196409702, 198950752, 210275032, 210280670, 223370143, 223628214, 237296750, 247494880, 252214719, 252478336
Target and Pathway
Target(s)	GPR40	Target Info	Agonist	[531990]
KEGG Pathway	Insulin secretion
Reactome	G alpha (q) signalling events
Reactome	Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
WikiPathways	GPCRs, Class A Rhodopsin-like
	Incretin Synthesis, Secretion, and Inactivation
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541619	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6485).
Ref 531990	Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. Mol Pharmacol. 2012 Nov;82(5):843-59.

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Drug Information