Drug General Information
Drug ID	D0Q7XS
Former ID	DIB008236
Drug Name	LP-0067
Synonyms	CXCR4 antagonists (autoimmune disease); CXCR4 antagonists (autoimmune disease), Leo Pharma
Indication	Autoimmune diabetes [ICD10:E08-E13]		Investigative	[543930]
Company	LEO Pharma A/S
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1cc(c2c(c1)nc(s2)CN(C1c2ncccc2CCC1)C)N1CCN(CC1)C
Target and Pathway
Target(s)	C-X-C chemokine receptor 4	Target Info	Antagonist	[543930]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Endocytosis
	Axon guidance
	Leukocyte transendothelial migration
	Intestinal immune network for IgA production
	Pathways in cancer
NetPath Pathway	IL2 Signaling Pathway
	IL4 Signaling Pathway
	Leptin Signaling Pathway
PANTHER Pathway	Axon guidance mediated by Slit/Robo
	Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database	S1P3 pathway
	CXCR4-mediated signaling events
	Syndecan-4-mediated signaling events
	HIF-1-alpha transcription factor network
	Ephrin B reverse signaling
Reactome	Binding and entry of HIV virion
	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Hematopoietic Stem Cell Differentiation
	HIV Life Cycle
	Cardiac Progenitor Differentiation
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543930	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71).
Ref 543930	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71).

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